Mild to moderate pain, fever, rheumatic fever, rheumatoid arthritis and osteoarthritis.
Adults: 500 mg or 1000 mg; for severe pain: 1000 mg in a single I.V. injection. Usual 24-hour dosage is 500 mg to 2 gm. In some cases, the daily dosage can be increased to 4 gm. Children: 10-25 mg/kg/day. For children from 6-10 years: 500 mg to 1 gm per day. Older than 11 years: 500 mg to 1 gm per day.
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It acetylates prostaglandin endoperoxide synthase and irreversibly inhibits its cyclo-oxygenase [COX] activity. This enzyme catalyzes the conversion of arachidonic acid to PGH2. It has two isoforms: COX-1 and COX-2. Acetylation of platelet cyclo-oxygenase prevents the synthesis of thromboxane A2 [a potent vasoconstrictor and inducer of platelet aggregation].
Renal impairment, gastric ulcers, mild diabetes, gout, severe anaemia, history of blood coagulation defects and those on anti-coagulants.
Hypersensitivity to NSAIDs, asthma, nasal polyposis, chronic urticaria, haemophilia, bleeding ulcer, haemorrhagic states.
GI disturbances, hypersensitivity reactions, blood dyscrasia, blurred vision, thirst, fever, increased bleeding time, bronchospasm.
After administration it dissociates into lysine and aspirin its 900mg is equivalent to 500mg of aspirin and it can be administered both orally and parenterally.