Vitiligo and psoriasis with UV light; severe refractory eczema; T cell lymphomas such as mycosis fungoides; polymorphic light eruptions.
Orally-0.6mg/kg is taken 2 hrs before UVA light exposure. [Topically: Lotion of 1% concentration is diluted 10 times and on the affected area 30 minutes before UVA exposure]. PUVA treatment can be given 2-3 times weekly. Treatments intervals must be 48hrs apart. An average of 20-30 PUVA treatments are required.
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It probably binds to DNA and inhibits DNA synthesis leading to reduced cell proliferation.
Immunotherapy increases the risk of squamous cell carcinoma; sunbathing 24hrs before and 48hrs after PUVA; UVA absorbing eyeglasses must be used during treatment; regular monitoring of eye functions.
Invasive squamous cell carcinoma; cataracts; melanoma; aphakia; disease conditions that are associated with photosensitivity such as lupus erythematosus, xeroderma pigment sum, and porphyria.
Nausea; erythema; itching; insomnia; depression; nervousness. S/E in PUVA therapy: Mild transient erythema; itching; edema; worsening SLE; hypertrichosis; acneiform eruptions; onycholysis; bullae formation; vesiculation; skin aging; cataract formation; squamous cell carcinoma; severe burns with over-exposure to light or sun.