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Mode of Action
Its exact mechanism of action is unknown. It may act by enhancing central noradrenergic and serotonergic activity, possibly through its antagonist activity at central presynaptic alpha2-adrenergic inhibitory autoreceptors and heteroreceptors. It shows no significant affinity for serotonin 5-HT1A or 5-HT1B receptors.
Avoid abrupt withdrawal, use in pregnancy and breastfeeding; history of bipolar depression; hepatic or renal or cardiac disorders; diabetes mellitus; psychosis; epilepsy; hypotension; angle-closure glaucoma; urinary retention.
Due to its anticholinergic antagonism avoid use in angle closure glaucoma, history of paralytic ileus; hypersensitivity to mirtazapine.