Prophylaxis of organ rejection in allogeneic renal transplantation (used with cyclosporine & steroids)
Cardiac:1.5 gm BD [in combination with cyclosporine and corticosteroids]. Renal: 1 gm BD in combination with cyclosporine and corti- costeroids].
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It is metabolized to mycophenolic acid, which is a selective, noncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase. The de novo synthesis pathway of guanosine nucleotides is inhibited without being incorporated into DNA. Its selectivity is due to the fact that T and B-lymphocytes are almost solely dependent for their proliferation on the inhibited de novo synthesis of purines, while other cell types can utilize salvage pathways.
GIT diseases; live attenuated vaccines; complete blood count performed as follows - weekly during the 1st month, twice monthly for the 2nd and the 3rd month of treatment, then monthly through the 1st yr