Prophylaxis of organ rejection in allogeneic renal transplantation (used with cyclosporine & steroids)
720mg BD on an empty stomach
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An inhibitor of inosine mono- phosphate dehydrogenase that blocks the de novo pathway of guanosine nucleotide synthesis. T- and B-lymphocytes rely mainly on this synthesis of purines unlike other cells.
GIT diseases; live attenuated vaccines; complete blood count performed as follows - weekly during the 1st month, twice monthly for the 2nd and the 3rd month of treatment, then monthly through the 1st yr
Pregnancy; allergy to the drug or its excipients
Pure red cell aplasia; opportunitistic infections; cancers; GIT bleeding; constipation; nausea; UTI; nausea; diarrhea; nasopharyngitis.