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Complete or partial reversal of opioid depression including respiratory depression; diagnosis of suspected or known acute opioid overdosage; as an adjunctive agent to increase blood pressure in the management of septic shock; reversal of opioid sedation after anaesthesia; Reversal of sedation and respiratory depression in neonate after maternal exposure to opioids.
Adult: Initial dose of 0.4-2mg, IV [or IM or SC when IV is not available]. If the desired effects are not attained repeat at 2-3 minute interval [up to 10mg]. Children & neonates: 0.01 mg/kg I.V. A subsequent dose of 0.1 mg/kg may be administered if the response is not satisfactory.
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