Myasthenia gravis, paroxysmal tachycardia, migraine and intestinal and post-operative atony, termination of effects of neuromuscular blocking agent
0.03 mg/kg to 0.07 mg/kg IV over a period of at least 60 secs (Max. dose: 0.07 mg/kg or up to a total of 5 mg, whichever is less
Mode of action
Brands containing this Ingredient
TIL Healthcare Pvt Ltd
Neon Laboratories Ltd
Sai Pharmaceuticals Ltd.
Distributed by Medisel (K) Limited
Medisel Kenya Ltd
Piramal Healthcare India Ltd
Galaxy Pharmaceuticals Ltd
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Mode of Action
It inhibits the hydrolysis of acetylcholine by competing with it for attachment to acetylcholinesterase at sites of cholinergic transmission. It has some direct cholinergic activity.
Bronchial asthma, cardiac rhythm disturbances, hypotension, epilepsy, peptic ulcers, Parkinsonism, elderly, impaired renal function. Aminoglycosides use as they accentuate neuromuscular blockage.
Pregnancy and lactation, concomitant use with depolarising muscle relaxants, during halothane/cyclopropane anaesthesia, diabetes, gangrene
GI disturbances, muscle cramps, increased salivation, headache, miosis, increased bronchial secretions, sweating, involuntary defaecation and micturition, nystagmus, hypotension, bradycardia.