Prevention of vascular spasm following subarachnoid haemorrhage.
Prevention, orally; 60mg every 4hours [total daily dose 360mg]. This should start within 4 days of subarachnoid haemorrhage and contin- ue for 21 days.
Treatment: IV infusion via central catheter. Initially: 1mg/hour, after 2hours; 2mg/hour as long as there is no severe drop in blood pressure.
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A calcium channel blocker
Avoid concomitant use of other calcium channel blockers; beta-blockers; tablets and infusion of nimodipine; grape juice; cerebral oedema or severely raised intracranial pressure; nephrotoxic drugs; impaired renal failure; pregnancy.
Hypotension; headache; GI disturb- ances; thrombocytopenia; feeling of warmth; temporary increase of liver enzymes after IV infusion.
A calcium channel blocker whose smooth relaxant effect preferentially acts on cerebral arteries