Acute uncomplicated infection, 50mg every 6 hours with food for 7 days [3 days usually adequate in women]; child over 3 months, 3mg/kg daily in 4 divided doses.
Severe chronic recurrent infection, 100mg every 6 hours with food for 7 days [dose reduced or discontinued if severe nausea].
Prophylaxis, 50–100mg at night; child over 3 months, 1mg/kg at night.
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Nitrofurans interfere with cell metabolism and cell wall synthesis by inhibiting several enzyme systems including acetyl coenzyme A.
Anaemia; diabetes mellitus; elect- rolyte imbalance; vitamin B and folate defic- iency; pulmonary disease; on long-term therapy, monitor liver function and monitor for pulmonary symptoms, especially in the elderly [discontinue if deterioration in lung function]; susceptibility to peripheral neuropathy; false positive urinary glucose [if tested for reducing substances]; urine may be coloured yellow or brown. Discontinue if paresthesia or haemolysis develops.
Renal disorders, pregnancy and lactation, porphyria.
disturbances, acute and chronic pulmonary reactions, peripheral neuropathy, lupus erythromatosus-like syndrome. Urticaria, rashes and pruritus.