Hypertension, 500mcg 2–3 times daily for 3–7 days, the initial dose on retiring to bed at night [to avoid collapse, see cautions]; increased to 1mg 2–3 times daily for a further 3–7 days; further increased if necessary to max. 20mg daily in divided doses. Congestive heart failure 500mcg 2–4 times daily [initial dose at bedtime], increasing to 4mg daily in divided doses; mainte- nance 4–20mg daily in divided doses [but rarely used]. Raynaud‘s syndrome [but efficacy not established, initially 500mcg twice daily [initial dose at bedtime] increased, if necessary, after 3– 7 days to usual maintenance 1–2mg twice daily.
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Alpha-adrenoceptor blocking agents
First dose may cause collapse due to hypotension [therefore should be taken on retiring to bed]; elderly; cataract surgery [risk of intra- operative floppy iris syndrome]; may affect performance of skilled tasks e.g. driving.
Congestive heart failure due to mechanical obstruction [e.g. aortic stenosis] hepatic impairment; renal imp
Dyspnoea; nervousness; urinary frequency; less commonly insomnia, paraesthesia, sweating, arthralgia, eye disorders, tinnitus, and epistaxis; rarely pancreatitis, flushing, vasculitis, bradycardia, hallucinations, worsening of narco- lepsy, gynaecomastia, urinary incontinence, and alopecia.