Allergic conditions; rheumatic arthritis; nephrotic syndrome; collagen diseases; fulminating SLE; bronchial asthma; status asthmaticus; severe chronic bronchial asthma; chronic ulcerative colitis; thrombocytopenia; organ transplant; shock [cardiogenic / traumatic].
Initially up to 10-20mg daily [max. 60mg daily]. Maintenance dose: 2.5-15mg daily. In acute attacks of asthma: High dose prednisone 30-40mg daily and reduced gradually once the attack is controlled. In chronic asthma: small doses taken in the morning to reduce the interference of circadian cortisol secretion. Child 1 month-18 years initially 1-2mg/kg once daily [usual max. 60 mg daily].
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It diffuses across cell membranes and forms a complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, binds to DNA, and stimulate transcription of messenger RNA [mRNA]. Messenger RNA leads to protein synthesis of various enzymes that are responsible for the effects of systemic corticosteroids
Patient monitor if used for prolonged use; use the lowest possible dose; use with caution in patients suffering from diabetes mellitus; CCF; hypertension; infections; thrombo-embolism; elderly; ureamia; and chronic renal failure.
Hypersensitivity to the drug; systemic fungal infections; live virus vaccination; IM use in idiopathic thrombocytopenic purpura; peptic ulceration; psychosis; osteoporosis; severe psycho-neurosis; TB; ocular herpes simplex; primary glaucoma.
Hypertension; hypersensitivity reactions; muscle mass loss; osteoporosis; throm-bo-embolism; thrombophlebitis; cardiac arrhyth-mias; insomnia; fatigue; hyperglyceamia; glau-coma; cushoid states; steroid psychosis and aggravation of pre-existing psychiatric condi-tions; syncopal episodes; GI disorders; impaired wound healing; thin fragile skin; acne; hirsutism; increased appetite and weight gain; convulsions; pancreatitis; spontaneous fractures; increased susceptibility to infections; peptic ulceration; myopathy; growth retardation in children; adrenal insufficiency; increased blood coagulability; masking of infections; skin pigmentation; immunosuppression.