Hyperthyroidism; as an adjunct to improve hyperthyroidism situation in preparation for surgical treatment or radioactive iodine therapy; when thyroidectomy is contraindicated or not advisable.
Adult: 300mg -900mg daily initially is
depending on severity of the condition. Maintenance dose: 100-150 mg daily.
Mode of action
Brands containing this Ingredient
Propylthiouracil, by Metro
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Mode of Action
It inhibits the synthesis of thyroid hormones by interfering with the incorpora- tion of iodine into tyrosyl residues of thyroglobulin. It also inhibits the coupling of these iodotyrosyl residues to form iodothyronine.
Prothrombin time should be monitored during therapy with the drug.
Hypersensitivity to the drug; in nursing mothers
Agranulocytosis; granulopenia; thrombocytopenia; aplastic anemia; drug fever; a lupus-like syndrome; hypoprothrombinemia; nephritis; interstitial pneumonitis; erythema nodosum; allergic reactions.
It is one of thethiocarbamide compounds with 6-membered ring, unlike
carbimazole, which has a 5-membered ring
Contraindications: Hypersensitivity to the drug; in nursing mothers