TB and Leprosy: 450-600mg daily in a single dose before breakfast. Brucellosis: 900mg daily at noon in combination with doxycycline 200mg at night for 45 days. Gonorrhoea: 900mg OD for 1-3days. Other infections: 600-1200mg daily in divided doses. Children: Over one month upto 20mg/kg.
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Inhibits DNA-dependent RNA polymerase activity in susceptible bacterial cells.
To be administered always with another tuberculostatic agent, pregnancy, impaired liver functions, undernourished patients, late pregnancy (can cause post-natal haemorrhage), immunologic reactions with intermittent therapy, discontinue immediately if signs of hepatocells are noted.
Jaundice, impaired liver functions, lactation and pregnancy, new born infants.
GI disturbances, skin reactions, liver dysfunctions, urine, sputum and tears discoloration, blood dyscrasia, oedema, flu syndrome, shortening of breath, menstruation disorders, acute renal failure, gout, gynaecomastia, aggreviate peptic ulcers, lupus like reactions, blurred vision. Safest antituberculous regimen for use in pregnancy is considered to be rifampin, isoniazid and ethambutol).