Single doses of 5 and 10 mg. Redosing: Doses should be separated by at least 2 hours, no more than 30mg should be taken in any 24-hour period. The safety of treating, on average, more than four headaches in a 30-day period has not been established.
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It is a 5HTI agonist, which is structurally related to serotonin. It induces de- creases in the firing of serotonergic [5-HT] neurons.
Renal, hepatic, neurological and CV disorders, epilepsy, sulphonamide sensitivity
Uncontrolled hypertension, SC use in patients with ischaemic heart disease, concomitant use with ergotamine preparations, management of hemiplegic or basilar migraine, IV use.
It is structurally as well as pharmacologically related to serotonin, (5-hydroxytryptamine, 5HT) differing structurally from serotonin mainly by the substitution of methane sulfonamide for the alcohol group on the indication sole ring.