amoeba in the liver (used mostly after the failure of metronidazole). Indications: Malarial treatment and prophylaxis where chloroquine resistant is not encountered, rheumatic arthritis, discoid erythematosus.
Prophylaxis - 500mg weekly from one week before exposure. Continue for 4 weeks after exposure. Acute attacks: Initially 4 tablets, then 2 six hours later then 2 OD x 3/7. Children: Initial dose; 10mg/kg (of Base) then 5mg/kg after 6hours then 50mg/kg OD x 3/7.
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Thought to inhibit heme poly- merase activity resulting in accumulation of free heme, which is toxic to the parasites
Hepatic disorders, alcohol, renal insufficiency, hepatotoxic drugs, history of myasthenia gravis, avoid operation of machinery, regular eye inspections on prolonged use, psoriasis.
Severe GI, neurological and blood disorders, pregnancy, hepatotoxic drugs, epilepsy, general psoriasis.