Adjunct to general anesthesia, to facilitate endotracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
1.V inj 600mcg/kg. Usual range:20-100mg.
Mode of action
Brands containing this Ingredient
Suxamethonium, by Medisel
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Mode of Action
As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. Subsequent neuromuscular transmission is inhibited so long as the adequate concentration of succinylcholine remains at the receptor site. It is rapidly hydrolyzed by plasma cholinesterase to inactive metabolites.
History of malignant hyperthermia, skeletal muscle myopathies, and known hypersensitivity to the drug. Due to the increased risks of severe hyperkalemia, which may result in cardiac arrest, it should not be administered in acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury.
Profound muscle relaxation resulting in respiratory depression; hypersensitivity reactions; cardiac arrest; malignant hyperthermia; arrhythmias; bradycardia; muscle fasciculation; jaw rigidity; hypertension or hypotension; post-operative muscle pain; rhabdomyolysis with possible myoglobinuric acute renal failure; excessive salivation; tachycardia; hyperkalemia; prolonged respiratory depression or apnea; increased intraocular pressure and rash.
Drug interactions: Drugs that may enhance the neuromuscular blocking action of succinylcholine include: oxytocin, certain non-penicillin antibiotics, β-adrenergic blockers, procainamide, lidocaine, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, metoclopramide, and terbutaline; drugs that reduce plasma cholinesterase activity like chronically administered oral contraceptives, glucocorticoids.