Dose: ‘Lower‟ urinary-tract infections, 400mg BD for 7-10 days [for 3 days for uncomplicated infections in women]. Chronic relapsing „lower‟ urinary-tract infections, 400mg BD for up to 12 weeks; may be reduced to 400mg OD if adequate suppression within first 4 weeks. Chronic prosta- titis, 400mg BD for 28 days.
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Interferes with bacterial DNA synthesis by inhibiting topoisomerase II [DNA gyrase] and topoisomerase IV.
Quinolones should be used with caution in children with a history of epilepsy or conditions that predispose to seizures, in G6PD deficiency, myasthenia gravis (risk of exacerbation). Exposure to excessive sunlight should be avoided (discontinue if photosensitivity occurs). Quinolones may induce convulsions in patients with or without a history of convulsions; taking NSAIDs at the same time may also induce them. May cause arthropathy in the weight-bearing joints of immature animals and are therefore generally not recommended in children and growing adolescents. However, the significance of this effect in humans is uncertain and in some specific circumstances short-term use of a quinolone in children is justified. Should be avoid in pregnancy and lactation.
History of tendon disorders related to quinolone use, documented hypersensitivity.
Tinnitus, epiphora; rarely pancreatitis; very rarely arrhythmias; also reported polyneuropathy and exfoliative dermatitis.