Severe staphylococcal infections; complicated skin and soft tissue infections, pneumonia, complicated urinary tract infections, bone & joint infections, and Infective endocarditis.
Complicated skin and soft tissue infections, pneumonia, and complicated urinary tract infections: Loading dose: 6 mg/kg BW every 12 hours for 3 IV treatments. Maintenance dose: 6 mg/kg BW IV or IM OD. Bone and joint infections and Infective endocarditis: Loading dose: 12 mg/kg BW every 12 hours for 3 -5 IV treatments. Maintenance dose: 12 mg/kg BW IV or IM OD. Duration of treatment: For infective endocarditis, a minimum of 21 days is advised. The maximum duration of treatment is 4 months.
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It is a glycopeptide antibiotic with bactericidal action against gram-positive [anaerobic and aerobic] infections.
Hearing loss, renal dysfunction, concomitant administration with other neuro-toxic and nephrotoxic drugs; sensitivity to vancomycin.