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Mode of Action
It is a recombinant plasminogen activator that catalyzes the cleavage of endoge- nous plasminogen to generate plasmin. Plasmin in turn degrades fibrin, which is the main component of the matrix of thrombi, thereby exerting its thrombolytic action.
Patients to be carefully evaluated before treatment.
Conditions that can be worsened by bleeding
Haemorrhage; cardiovascular events such as recurrent ischaemia/angina, hypotension, heart failure/pulmonary oedema, arrhythmias; mitral regurgitation.