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Testosterone replacement therapy in many hypogonadal disorders, osteoporosis due to androgen deficiency
IM dose for 1000 mg of testosterone undecanoate in 4 ml of oily vehicle: 1000mg injected in intervals of 10-14 weeks. It is advisable to reduce the first interval to 6wks in order to reduce the time until steady state conditions are reached. (During the initial time of treatment the mean concentration of testosterone is slowly increasing with each injection. Steady state is reached when the amount of testosterone supplied with an injection replaces exactly what has been metabolized from the intramuscular depot). Oral dose: Initially 120-160mg daily for 2-3wks. Maintenance dose; 20-60mg BD
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