Induction of general anesthesia; used alone in short surgical procedures; short term control of seizures; elevated intracranial pressure; cerebral protection in focal cerebral ischemia as observed in head injuries and status epilepticus [this protection is due to the fact that thiopentone reduces cerebral metabolic rate and blood flow]
Induction and maintenance: Adult - IV bolus
2-5mg/kg. with additional 25-50mg when needed. In elderly or debilitated the dose is reduced to 1-2.5mg /kg. Child: IV bolus, 5-6mg/kg. Neonate: IV bolus 2-3mg/kg. Seizure control: Adult, IV bolus, 50-125mg
[increments of 25mg]. Child: IV bolus, 1.5- 3.5 mg /kg. Cerebral Protection: Adult & child, IV bolus, 1.5- 3.5 mg /kg
Mode of action
Brands containing this Ingredient
Thiopentone, by Medisel
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Mode of Action
It is thought to act by potentiating the action of inhibitory neurotransmitter gamma-aminobutyric acid [GABA] receptors as well as depressing the actions of excitatory neurotransmitters in CNS.
cerebral protection in focal cerebral ischaemia as observed in head injuries and status epilepticus (this protection is due to the fact that thiopentone reduces cerebral metabolic rate and blood flow)
Hypersensitivity to barbiturates; porphyria
Hypotension; myocardial depression; respiratory depression; garlic-like taste during induction; erythema; pain at injection site; laryngospasm and rarely bronchospasm; anaphylaxis [rarely]; extravasations can cause tissue necrosis. The intra-arterial injection can cause arterial spasm, thrombosis, and gangrene.
Drug interactions: It is physically incompatible [forms precipitate] with atracurium, vecuronium, and suxamethonium. [To reduce this, separate IV line should be used, otherwise flush IV cannula with normal saline after injecting each drug]. It can induce liver enzymes and affect the metabolism of other drugs