For children: 2mg/m2 weekly. For Adult: 1.4mg/m2 weekly
Consult specialist literature for further information.
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It binds to tubulin [the protein subunit of the microtubules that form the mitotic spindle] forming complexes that prevent the polymerization of the tubulin subunits into micro-tubules. It also induces depolymerization of microtubules. These actions lead to inhibition of microtubule assembly and cellular metaphase arrest.
Avoid extravasation as it causes marked irritation; chickenpox; herpes zoster. It must be used only under constant supervision by physicians experienced in therapy with cytotoxic agents due to its low therapeutic index; increased incidence of infections; laboratory and supportive services must be available for haematologic and chemistry monitoring; it is fatal when given intrathecally
Hypersensitivity to the drug; demyelinating form of Charcot-Marie-Tooth syndrome
Alopecia [most common S/E]; leukopenia; neuritic pain; constipation; paresthesia; difficulty in walking; slapping gait; loss of deep-tendon reflexes; muscle wasting; allergic reactions; weight loss; nausea and vomiting; oral ulceration; diarrhoea, paralytic ileus; intestinal necrosis; polyuria; dysuria; urinary retention; hypertension; hypotension; Serious bone-marrow depression is normally not a major dose-limiting side effect.
///A vinca alkaloid isolated from Cantharanthus roseus.
///Drug interactions: It may raise the concentration of blood uric acid hence interacts with allopurinol, colchicine, probenecid and sulfinpyrazone.