Prophylaxis and treatment of Thiamine deficiency; supplement in the following conditions â alcoholism, burns, chronic fever, gastrectomy, haemodialysis, chronic hepatic-biliary tract disease, hepatic function disorder, hyperthyroidism, prolonged infection, prolonged stress; treatment of maple syrup urine disease; treatment of pyruvate carboxylase deficiency; treatment subacute necrotizing encephalomyelopathy; treatment of hyperalaninaemia.
Mild chronic deficiency: 10-25mg daily. Severe deficiency; 200-300mg daily. Multivitamin therapy is concomitantly given.
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It combines with ATP to form a coenzyme, thiamine pyrophosphate, which is necessary for carbohydrate metabolism.
Hypersensitivity to thiamine, Wernicke's encephalopathy.
||| Alcoholics often become deficient of this vitamin, perhaps because of their eating habit. Its deficiency causes beriberi, in which there may be high output heart failure, peripheral neuritis or encephalopathy.
||| Natural Sources: Lightly milled wheat, unpolished maize and rice, green vegetables, beef, liver and egg york.