Prevention of skeletal related events (pathological fractures, spinal compression, radiation or surgery to bone, or tumor-induced hypercalcemia) in patients w/ advanced malignancies involving bone; Treatment of hypercalcemia of malignancy
Prevention of skeletal related events (pathological fractures, spinal compression, radiation or surgery to bone, or tumor-induced hypercalcemia) in patients w/ advanced malignancies involving bone Recommended dose: 4 mg (diluted with 100ml NaCl 0.9% w/v or glucose 5% w/v soln) given as a 15-min IV infusion every 3-4 wk. Reduce dose in patients with preexisting mild to moderate renal impairment. Treatment of hypercalcemia of malignancy (HCM: Recommended dose- 4 mg given as a single 15-min IV infusion. No dose adjustment in patients with mild to moderate renal impairment. Without hypercalcemia 500 mg oral Ca supplement and 400 iu vitamin D daily.
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Inhibitor of osteoclastic bone resorption. It also possesses several antitumor properties that would contribute to its overall efficacy in the treatment of metastatic bone disease.
Patients should be well hydrated. Monitor serum levels of Ca, phosphate, Mg & serum creatinine. Severe occasional incapacitating bone, joint and/or muscle pain in patients taking bisphosphonates. Dose reduction in pre-existing mild to moderate renal impairment.
Pregnancy, breastfeeding women, hypersensitivity to zoledronic acid or other bisphosphonates or any of the excipients of the drug.
Hypophosphatemia, flu-like syndrome, headache, elevation of serum creatinine and blood urea, renal impairment, anemia, conjunctivitis, GI reactions, serum Ca may fall to asymptomatic hypocalcemic levels, hypersensitivity reactions, hypertension, shortness of breath, cough, dizziness, paresthesia, taste disturbances, hypoesthesia, hyperesthesia, tremor, local reactions at infusion site, rash, pruritus.
It also possesses several antitumor properties that would contribute to its overall efficacy in the treatment of metastatic bone disease.